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Abnormal expressed co-stimulating factors and their relationship to activation of T lymphocytes in patients with aplastic anemia
Author(s): 
Pages: 152-155
Year: Issue:  2
Journal: CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY

Keyword:  再生障碍性贫血淋巴细胞异常活化细胞表型变化;
Abstract: 目的研究再生障碍性贫血(AA)患者骨髓(BM)及外周血(PB)淋巴细胞及其活化相关分子的表达及临床意义.方法采用单色和双色免疫荧光标记法、流式细胞仪分析AA患者的BM和PB中淋巴细胞膜分子的表达.结果 AA患者BM和BP中CD8+细胞增加,CD4/CD8比例下降,BM中CD25+细胞和HLA-DR+细胞增多,急性AA增加尤为显著(P<0.01),BM中CD16+或CD56+细胞也明显增多(P<0.05);双标记分析提示T细胞主要为CD8+细胞;急性AA患者CD8+-CD25+细胞显著增多(P<0.01),AA患者BM中淋巴细胞活化相关分子表达增多,尤其是4-1BB+、CD95L+和CD40L+细胞显著增多(P<0.01).结论 AA患者BM中淋巴细胞活化相关膜分子增多,是AA免疫功能异常及最终导致造血功能衰竭的原因之一.
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