Clinical study on Compound Tianxian Capsules combined with radiotherapy in the treatment of advanced esophageal cancer
Author(s): WANG Xiu-yan, ZHANG Yan, Department of Gastroenterology, Shenyang 242 Hospital
Pages: 279-282
Year: 2015 Issue: 3
Journal: World Phytomedicines
Keyword: Compound Tianxian Capsules; radiotherapy; esophageal cancer; efficacy;
Abstract: Objective To explore the effect of Compound Tianxian Capsules combined with radiotherapy in the treatment of advanced esophageal cancer. Methods The patients with advanced esophageal cancer(64 cases) who were cured in Shenyang 242 Hospital from December 2012 to August 2014 were randomly divided into control and treatment groups, and each group had 32 cases. The patients in two groups were accepted treatment with help of 6 MV- X line linear accelerator by three dimensional conformal radiotherapy irradiation method. The total dose was 60 — 70 Gy, and conventional therapy was divided into five times a week during 6 — 7 weeks, 2 Gy/time. The patients in the treatment group were po administered with Compound Tianxian Capsules, 30 min after meals, 3 capsules /time, three times daily. A course included two months. Radiotherapy was adopted in patients in treatment group after two weeks, and other treatment was the same as the control group. After the treatment of radiotherapy for three months, the efficacies, adverse reactions, and quality of life were evaluated. Blood samples were collected 1 d before treatment and second day after treatment to detect peripheral blood NK cell activity and the levels of NO and IL-12. Results After treatment, the efficacies in the control and treatment groups were 62.5% and 87.5%, respectively, and there were differences between two groups(P < 0.05). There were differences of adverse reactions and Karuafsky scores after treatment between two groups(P < 0.05). Peripheral blood NK cell numbers in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). Peripheral blood NK cell numbers in the treatment group were significantly lower than those of the control group, with difference between two groups(P < 0.05). After treatment, the levels of NO and IL-12 in the treatment group were better than those of control group, with significant difference between two groups(P < 0.05). The levels of IL-12 in two groups after treatment were significantly decreased, while the level of NO were decreased, and the difference was statistically significant in the same group(P < 0.05, 0.01). Conclusion Compound Tianxian Capsules combined with radiotherapy has the good clinical effect in the treatment of advanced esophageal cancer, and improve life qualities o patients.
Pages: 279-282
Year: 2015 Issue: 3
Journal: World Phytomedicines
Keyword: Compound Tianxian Capsules; radiotherapy; esophageal cancer; efficacy;
Abstract: Objective To explore the effect of Compound Tianxian Capsules combined with radiotherapy in the treatment of advanced esophageal cancer. Methods The patients with advanced esophageal cancer(64 cases) who were cured in Shenyang 242 Hospital from December 2012 to August 2014 were randomly divided into control and treatment groups, and each group had 32 cases. The patients in two groups were accepted treatment with help of 6 MV- X line linear accelerator by three dimensional conformal radiotherapy irradiation method. The total dose was 60 — 70 Gy, and conventional therapy was divided into five times a week during 6 — 7 weeks, 2 Gy/time. The patients in the treatment group were po administered with Compound Tianxian Capsules, 30 min after meals, 3 capsules /time, three times daily. A course included two months. Radiotherapy was adopted in patients in treatment group after two weeks, and other treatment was the same as the control group. After the treatment of radiotherapy for three months, the efficacies, adverse reactions, and quality of life were evaluated. Blood samples were collected 1 d before treatment and second day after treatment to detect peripheral blood NK cell activity and the levels of NO and IL-12. Results After treatment, the efficacies in the control and treatment groups were 62.5% and 87.5%, respectively, and there were differences between two groups(P < 0.05). There were differences of adverse reactions and Karuafsky scores after treatment between two groups(P < 0.05). Peripheral blood NK cell numbers in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). Peripheral blood NK cell numbers in the treatment group were significantly lower than those of the control group, with difference between two groups(P < 0.05). After treatment, the levels of NO and IL-12 in the treatment group were better than those of control group, with significant difference between two groups(P < 0.05). The levels of IL-12 in two groups after treatment were significantly decreased, while the level of NO were decreased, and the difference was statistically significant in the same group(P < 0.05, 0.01). Conclusion Compound Tianxian Capsules combined with radiotherapy has the good clinical effect in the treatment of advanced esophageal cancer, and improve life qualities o patients.
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