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Study of resting-state functional MRI in patients with rheumatoid arthritis
Author(s): 
Pages: 17-20
Year: Issue:  1
Journal: Radiologic Practice

Keyword:  ArthritisrheumatoidMagnetic resonance imagingDiagnosis;
Abstract: 目的:探讨类风湿关节炎(RA)患者静息态下局部脑区的自发神经活动.方法:利用3.0T磁共振扫描仪采集年龄、性别及受教育程度相匹配的35例RA患者(RA组)和35例正常对照者(NC组)静息态功能磁共振(rs-fMRI)数据,应用低频振幅(ALFF)方法分析、比较两组受试者大脑自发活动的差异.结果:与正常对照组相比,RA患者ALFF值增高区位于双侧前扣带膝下部、双内侧眶额皮层以及双侧岛叶,ALFF值降低区主要位于双侧距状回、右舌回、右楔叶、左枕中回(P<0.05,AlphaSim校正).结论:RA患者静息态下神经活动存在异常,增高区可能反映与疾病相关的运动决策功能改变,功能降低区可能反映视觉功能改变.
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