Author(s): LI Wei-hong, LI Bin, Reproductive Health and Infertility Center, First Affiliated Hospital, Chongqing Medical University, Department of Pharmacology, College of Pharmaceutical, Third Military Medical University
Pages: 19-23
Year: 2015 Issue:  1
Journal: Chinese Journal of Clinical Pharmacology and Therapeutics
Keyword:  aspirin; polycystic ovary syndrome; inflammatory responses;
Abstract: AIM:To study the effects of aspirin on inflammatory responses in polycystic ovarian syndrome(PCOS)rats. METHODS:Combined administration of human HCG and insulin was used for establishing PCOS rat model,PCOS rat weight,ovarian weight,morphology.The effects of aspirin on the levels of serum TNF-α,IL-6and insulin and the expression of IL-6and TNF-α mRNA in ovarian tissue were observed.RESULTS:Aspirin treatment significantly reduced the rat weight and ovary weight in PCOS rats,the ovarian pathological changes,levels of TNF-α,IL-6and insulin in serum and expressions of IL-6and TNF-αmRNA in ovarian tissue were obviously reduced compared with the PCOS rats.CONCLUSION:Aspirin therapy has protective effect on PCOS rats and the effect is closely related to its anti-inflammatory effect.