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Influence of Hypertension on the Expression of MAG and MBP in the Sciatic Nerve in Rats with Diabetic Peripheral Neuropathy
Pages: 188-190
Year: Issue:  2
Journal: Research of Traditional Chinese Medicine

Keyword:  hypertensiondiabetic peripheral neuropathymyelin associated glycoproteinmyelin basic protein;
Abstract: Objective To investigate the effects of hypertension(HTN)on the expression of myelin associated glycoprotein(MAG)and myelin basic protein(MBP)in the sciatic nerve in rats with diabetic peripheral neuropathy(DPN).Methods The rats were randomly divided into normal group,DPN group and HTN+DPN group.After 4 weeks of modeling,the blood sugar,blood pressure and conduction velocity of sciatic nerve were measured,the mRNA expression of MBP and MAG in the sciatic nerve was detected by RT-PCR.Results After 4weeks of modeling,compared with normal group,the blood sugar were increased in DPN group and HTN+DPN group,while the conduction velocity of sciatic nerve was decreased,the mRNA expression of MAG and MBP in sciatic nerve were increased(P <0.01).Compared with DPN group,the blood pressure were increased in HTN+DPN group,and the conduction velocity of sciatic nerve was decreased,the mRNA expression of MAG was increased and the expression of MBP was decreased in sciatic nerve(P <0.01).Conclusion Hypertension can contribute to worsening of DPN by elevating MAG and decreasing MBP in sciatic nerve,and inhabiting myelination.
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