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zheng chang gao zhi xue ya ban bu tong niao suan shui ping ren qun xue jiang da nei pi su -1 shui ping guan cha
Author(s): 
Pages: 236-238
Year: Issue:  2
Journal: Research of Traditional Chinese Medicine

Keyword:  正常高值血压高尿酸血症大内皮素-1;
Abstract: 目的观察正常血压及正常高值血压伴不同尿酸水平人群血浆大内皮素-1(big ET-1)水平间接了解血管内皮情况。方法根据2010年中国高血压防治指南,将160例健康体检者分为正常血压组(n=58)和正常高值血压组(n=102),依据血尿酸及血压水平分成3组:正常血压+正常尿酸组(A组)58例,正常高值血压+正常尿酸组(B组)52例,正常高值血压+高尿酸血症组(C组)50例。用酶联免疫吸附试验(ELLISA)检测血浆big ET-1水平。结果 A组、B组、C组big ET-1水平分别为7.37ng/L±6.94ng/L、10.12ng/L±0.46ng/L、3.82ng/L±2.47ng/L,3组比较差异有统计学意义(F=19.85,P=0.001),组间两两相比差异均有统计学意义(P<0.01);多元线性回归分析显示big ET-1与收缩压、尿酸相关(P<0.05或P<0.01)。结论正常高值血压阶段血浆big ET-1水平明显升高,合并高尿酸血症时big ET-1进一步升高,间接反映正常高值血压阶段已经出现了内皮功能损害,合并高尿酸血症时,内皮功能的损害更明显。
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