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Therapeutic of Gushen No.1 on rat anti glomerular basement membrane nephritis in rats and its mechanism
Author(s): 
Pages: 126-131
Year: Issue:  2
Journal: World Phytomedicines

Keyword:  Gushen No.1rat anti glomerular basement membrane nephritisIg G;
Abstract: Objective To investigate the therapeutic effect of Gushen No. 1 on rat anti glomerular basement membrane(GBM) nephritis of rats, and study its possible mechanisms. Methods Rat anti-GBM antibody produced in rabbit was injected to rats to make Masugi nephritis model. After 3 weeks, index was observed after administrated Gushen No. 1, such as on urine protein, blood biochemistry, kidney index, kidney pathology, and Ig G of rats and rabbit in GBM. Results Gushen No. 1 could significantly reduce rat’s urine protein, serum urea nitrogen(BUN), serum creatinine(Cr), increase serum total protein(TP), and albumin(Alb). It also had therapeutic on significant reducing of renal index, improvement of kidney pathology, and reducing Ig G of rats and rabbit in GBM. Conclusion It is obvious that Gushen No. 1 can alleviate kidney lesions and improve kidney function by reducing Ig G of rats and rabbit in GBM.
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