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Clinical study on silibin meglumine combined with polyene phosphatidylcholine in treatment of fatty liver
Author(s): 
Pages: 176-179
Year: Issue:  2
Journal: World Phytomedicines

Keyword:  Silibin Meglumine TabletsPolyene Phosphatidylcholine CapsulesReduced Glutathione Tabletsfatty liverALTAST;
Abstract: Objective To investigate the clinical efficacy and safety of silibin meglumine combined with polyene phosphatidylcholine in treatment of fatty liver. Methods The patients with fatty liver(150 cases) of Suzhou Municipal Hospital from June 2013 to June 2014 were randomly divided into control(n = 74) and treatment(n = 76) groups. The patients in the control group were po administered with Reduced Glutathione Tablets(4 tablets/time, three times daily) and Polyene Phosphatidylcholine Capsules(2 grains/time, three times daily). The patients in the treatment group were po administered with Silibin Meglumine Tablets,(2 tablets/time, three times daily) and Polyene phosphatidylcholine Capsule(the usage and dosage was the same with the control group). After the treatment, the efficacy was evaluated, and the changes of ALT, AST, TG, TC, CT imaging, and VTQ value were compared in two groups. Results The efficacies in the control and treatment groups were 82.43% and 93.42%, respectively, and there were differences between two groups(P < 0.05). After treatment, ALT, AST, TG, TC, CT imaging changes and VTQ value in two groups were significantly reduced, and the difference was statistically significant in the same group(P < 0.05). The improvement degree in the treatment group was better than that in the control group with significant difference between two groups(P < 0.05). After treatment, CT images showed that patients in the two groups got better than before treatment. The proportion of patients with fatty liver under mild degree in the treatment was significantly higher than that in the control group with significant difference between two groups(P < 0.05). Conclusion Silibin meglumine combined with polyene phosphatidylcholine has the good clinical effect in treatment of fatty liver, and can effectively improve liver function and deposition of fat in liver, which is worth clinical promotion.
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