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Protection of Danggui Shaoyao Powder water extracts on hepatic injury induced by antituberculosis drugs in rats and its mechanism
Author(s): 
Pages: 120-125
Year: Issue:  2
Journal: World Phytomedicines

Keyword:  Danggui Shaoyao Powderwater extractsliver injuryTNF-αlipid peroxidationprotection;
Abstract: Objective To investigate the protection of Danggui Shaoyao Powder water extracts on the hepatic injury induced by antituberculosis drugs in rats. Methods Sixty rats were divided randomly into six groups: Normal group, model group, tiopronin group(60 mg/kg), and Danggui Shaoyao Powder water extracts(8, 16, and 32 g/kg) groups. All groups were treated for 8 weeks. The levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in serum, as well as the superoxide dismutase(SOD) and malondialdehyde(MDA) in serum and liver were determined. Expression of hepatic tumor necrosis factor-α(TNF-α) m RNA was analyzed by RT-PCR method and its protein levels were assayed by Western Blotting method. Results Compared with model group, Danggui Shaoyao Powder water extracts at medium and high doses significantly reduced serum ALT and AST levels, elevated serum and liver SOD activities, down-regulated serum and liver MDA levels and reduced liver TNF-α m RNA and protein levels. Conclusion Danggui Shaoyao Powder water extracts has protective effects on the hepatic injury induced by antituberculosis drugs in rats which may be related to its inhibition of TNF-α and lipid peroxidation.
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