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Clinical observation of Shenqi Jiangtang Capsules combined with Glyburide Tablets in treatment of type 2 diabetes mellitus
Author(s): 
Pages: 161-165
Year: Issue:  2
Journal: World Phytomedicines

Keyword:  Shenqi Jiangtang CapsulesGlyburide Tabletstype 2 diabetes mellitusefficacy;
Abstract: Objective To study the efficacy and security of Shenqi Jiangtang Capsules combined with Glyburide Tablets in treatment of type 2 diabetes mellitus. Methods The patients with type 2 diabetes mellitus(104 cases) in Kangjian Community Health Service Center of Xuhui District from January 2013 to June 2014 were randomly divided into control and treatment groups, and each group had 52 cases. The patients in the control group were po administered with Glyburide Tablets 0.5 h before meals, 2.5 mg/time, three times daily. The patients in the treatment group were po administered with Shenqi Jiangtang Capsules at the basis of the control group, 3 capsules/time, three times daily. The patients in two groups were treated for 8 weeks. The level of fasting plasma glucose(FPG), the 2-hour postprandial blood glucose(2 h PG), Hb A1 C, blood glucose target rate, blood glucose standard time, and score of TCM syndrome in two groups before and after treatment were determined. Efficacy and the incidence of hypoglycemia between two groups before and after treatment were also compared. Results After treatment, FPG, 2h PG, and Hb A1 C of two groups were significantly decreased, and the difference was statistically significant in the same group before and after treatment(P < 0.05, 0.01). After treatment, FPG, 2 h PG, and Hb A1 C in treatment group were lower than those in the control group, and there were differences between two groups(P < 0.05, 0.01). Blood glucose standard time, changes of blood glucose, and hypoglycemia incidence in the treatment group were lower than those in the control group, and there were differences between two groups(P < 0.05). After treatment, the score of TCM syndrome in two groups were significantly reduced, and the difference was statistically significant in the same group before and after treatment(P < 0.05, 0.01). After treatment, the indicators in the treatment group were lower than those in the control group, and there were differences between two groups(P < 0.05). The efficacies in the treatment and control groups were 94.23% and 84.62%, respectively, with differences between the two groups(P < 0.05). Patients in two groups did not appear serious adverse reactions. Conclusion Shenqi Jiangtang Capsules combined with Glyburide Tablets has the good clinical effect in treatment of controlling blood glucose, shortening blood glucose target rate, reaching blood glucose standard time, and lowering incidence of hypoglycemia on the patients with type 2 diabetes mellitus than Glyburide Tablets alone. It exactly improves the clinical curative effect and helps reduce long-term complications, which is worth clinical application.
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