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Clinical study on recombinant human growth hormone in treatment of neonatal sepsis
Author(s): 
Pages: 157-160
Year: Issue:  2
Journal: World Phytomedicines

Keyword:  recombinant human growth hormone for injectionneonatal sepsisCK-MBCK;
Abstract: Objective To investigate the efficacy of recombinant human growth hormone(rh GH) in treatment of neonatal sepsis, the influences of recombinant human growth hormone about CK-MB, CK, and serum inflammatory factors. Methods Children(80 cases) with neonatal sepsis who came to the Armed Police Hebei Corps Hospital from February 2011 to May 2014 were randomly divided into the control and treatment groups, and each group had 40 cases. The patients in control group were given comprehensive treatment, and at the same time they were iv administered with corresponding antibiotics. The patients in treatment group were sc administered with Recombinant Human Growth Hormone for injection every other day, 0.1 U/kg, and other treatment was the same as the control group. The patients in the two groups were treated for 10 d. After the treatment, the efficacy was evaluated, at the same time the changes of CK-MB, CK, NGAL, TNF-α, and IGF-1 in two groups were compared. Results The efficacies in the control and treatment groups were 77.5% and 90.0%, respectively, and there were differences between two groups(P < 0.05). After treatment, the levels of CK, CK-MB, NGAL, TNF-α, and IGF-1in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the improvement degree of the treatment group was better than that in the control group, with significant differences between two groups(P < 0.05). Conclusion Recombinant human growth hormone has the good clinical effect in treatment of neonatal sepsis, and can reduce myocardial injury, which can relieve systemic inflammatory response.
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