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Clinical observation of Live Combined Bifidobacterium and Lactobacillus Tablets combined with Enteral Nutritional Suspension in improvement of sepsis
Author(s): 
Pages: 180-183
Year: Issue:  2
Journal: World Phytomedicines

Keyword:  Live Combined Bifidobacterium and Lactobacillus TabletsEnteral Nutritional SuspensionsepsisALBPATRFPCT;
Abstract: Objective To explore the clinical effect of Live Combined Bifidobacterium and Lactobacillus Tablets combined with Enteral Nutritional Suspension in the improvement of sepsis. Methods The patients with sepsis(100 cases) of Shenyang the Fourth Hospital of People from May 2012 to April 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were given enteral nutritional suspension on the basis of symptomatic treatment, beginning from 30 m L/h, and gastric retention amount were monitored every 4 h. Nasal feeding amounts were increased according to the situation of patients, and the amounts of maintaining were general 60-100 m L/h. The patients in the treatment group were given Live Combined Bifidobacterium and Lactobacillus Tablets on the basis of control group, 4 tablets/time, dissolved with warm boiling water after crushed, three times daily. The patients in two groups were treated for 8 d. The changes of nutrient indexes including ALB, PA, TRF, blood glucose, infectious indexes including CRP, PCT before treatment and 2, 4, 8 d after the treatment in two groups were compared. At the same time, incidence of adverse reactions in two groups were compared. Results ALB, PA, and TRF in the control group was significant improved on the eighth day of treatment, while these nutrition indexes in the treatment group were significantly increased on the fourth and eighth day of treatment, and the difference was statistically significant in the same group(P < 0.05). ALB, PA, and TRF in the treatment group were higher than those in the control group on the fourth and eighth day of treatment, and there were differences between two groups(P < 0.05). Blood glucose in the treatment group was significantly decreased on the fourth and eighth day of treatment, and the difference was statistically significant in the same group(P < 0.05). Blood glucose in the treatment group was significantly lower than that in the control group on the fourth and eighth day of treatment, and there were differences between the two groups(P < 0.05). CRP and PCT in the two groups were significantly reduced on the second, fourth and eighth day of treatment, and the difference was statistically significant in the same group(P < 0.05). The extent of these indicators in the treatment group was better than those of control group, and there were differences between the two groups(P < 0.05). Conclusion Live Combined Bifidobacterium and Lactobacillus Tablets combined with Enteral Nutritional Suspension has good nutrition support in patients with sepsis, and can improve stress hyperglycemia, while can inhibit inflammatory reaction and reduce the incidence of gastrointestinal adverse reactions, which is worth clinical promotion.
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