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Clinical observation of alendronate sodium combined with salmon calcitonin in treatment of osteoporotic femoral intertrochanteric fractures
Author(s): 
Pages: 199-202
Year: Issue:  2
Journal: World Phytomedicines

Keyword:  Alendronate Sodium TabletsSalmon Calcitonin Injectionosteoporosisfemoral intertrochanteric fractures;
Abstract: Objective To explore the efficacy of alendronate sodium combined with calcitonin in treatment of osteoporotic femoral intertrochanteric fractures. Methods The patients with elderly osteoporotic femoral intertrochanteric fractures(106 cases) of the Fifth People’s Hospital of Hengshui City from February 2011 to October 2013 were randomly divided into control and treatment groups, and each group had 53 cases. The patients of two groups were given fixation. The patients in the control group were sc Salmon Calcitonin Injection on the first day after the operation, 50 U/time, once daily, and 50 U/time every other day after 2 — 4 weeks. The patients in the control group were po Alendronate Sodium Tablets, at least 30 min before breakfast with 200 m L warm water on an empty stomach, 1 tablet/time, once daily. Other treatment was the same with the control group. The patients in two groups were treated for 36 weeks. The changes of VAS score, Harris score, mineral density of hip bone, healing time, and biochemical indexes were compared between two groups. Results After treatment, VAS score, Harris score, and mineral density of hip bone in two groups were improved, and the difference was statistically significant in the same group(P < 0.05). After treatment, mineral density of hip bone in treatment group was higher than that in the control group, with significant difference between two groups(P < 0.05). Osteocalcin, blood scales and urinary calcium/urinary creatinine in two groups were significantly increased, while the blood calcium and hydroxyproline/urinary creatinine were reduced, and the difference was statistically significant in the same group(P < 0.05). And the improvement levels of osteocalcin, blood scales, alkaline phosphatase, and hydroxyproline/urinary creatinine in the treatment group were better than those in control group, with significant difference between two groups(P < 0.05). Conclusion Alendronate sodium combined with calcitonin has no significant effect on fracture healing and functional recovery, but has obvious enhancement effect on the promotion of bone mineral density, which can promote the absorption of blood calcium.
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