Author(s): CUI Hongquan, GUO Xintian, JI Lei, REN Guangqing
Pages: 815-819
Year: 2014 Issue:  6
Journal: Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Version)
Keyword:  Bacterial culture; Pathogenic bacteria; Drug resistance; Clinical research;
Abstract: Objective To investigate the drug resistance of pathogenic bacteria and the regularity of the onset of antibacterial drugs for different areas and different seasons. Methods The results of drug sensitivity test for pathogenic bacteria isolated in 2013 were analyzed retrospectively. The results of classiifcated according to the quarters, then the fourth quarter was taken as samples and compared with the ifrst three quarters. Results The samples in the fourth quarter of 2014 were 3 200, from which there were 510 strains bacteria cultivation, with the positive rate of 15.93%. Among which, there were 326 (63.92%) strains of Gram-negative bacteria, 157 (30.78%) strains of Gram-positive bacteria, and 27 (5.29%) strains other bacteria. The top of several types of bacteria were E. coli (30.00%, 153/510), Klebsiella bacteria (15.68%, 80/510), Pseudomonas aeruginosa (61/510, 11.96%), Staphylococcus aureus (34/510, 6.67%) and Acinetobacter baumannii (4.71%, 24/510), respectively. The drug resistance to penicillin and generation cephalosporins were higher of E. coli, with 83.66%and 71.24%, respectively. The drug resistance still high of Klebsiella pneumoniae to penicillin, and the drug resistance to the family of other kinds of antimicrobial all below 30%. The drug resistance of Staphylococcus aureus to penicillin G was 94.1%. The drug resistance was still high of Pseudomonas aeruginosa in fermentation bacteria to the main antibacterial drugs. Conclusion There was no association of the drug resistance of the main pathogenic bacteria and seasonal change, but actually has the trend of increased year by year.