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il-17 zai you nian te fa xing guan jie yan huan er xue qing zhong de biao da shui ping ji yi yi
Author(s): 
Pages: 59-61
Year: Issue:  1
Journal: Hebei Medical Journal

Keyword:  特发性关节炎幼年白细胞介素-17ELISA;
Abstract: 目的:通过检测幼年特发性关节炎( JIA)患儿血清中IL-17的水平,了解其在幼年特发性关节炎的发病机制中的作用。方法选择确诊JIA患儿54例,其中17例全身型定为病例1组,20例多关节型定为病例2组,17例少关节型定为病例3组,将同时期在健康查体儿童32例定为健康对照组,检测记录各组血清IL-17水平和病例组患儿ESR、CRP及肿痛关节数。分析4组间IL-17水平差异和JIA患儿IL-17水平与ESR、CRP及肿痛关节数的相关性。结果病例1组、病例2组、病例3组、健康对照组各组间IL-17水平差异有统计学意义( F =54 b.680, P <0.01),JIA患儿血清IL-17水平与ESR及CRP无明显相关性( r =0.050, P =0.721;r =0.263, P =0.055),而与肿痛关节数呈正相关( r =0.433, P =0.001)。结论 JIA患儿血清中IL-17的表达水平显著升高,且与常用的临床炎性指标ESR、CRP无显著相关,而与肿痛关节数呈正相关,提示IL-17在关节局部炎症中起重要作用。
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