The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
hai nan di qu guo chan rui fen tai ni jing mai ba kong shu zhu de qun ti yao dai dong li xue yan jiu
Author(s): 
Pages: 132-134
Year: Issue:  1
Journal: Hebei Medical Journal

Keyword:  瑞芬太尼群体药代动力学;
Abstract: 目的:探讨国产瑞芬太尼在海南地区群体药代动力学变化规律及海南人国产瑞芬太尼最适靶控输注参数。方法前瞻性分析400例临床择期手术患者,通过建立液-液萃取毛细管气相色谱-质谱联用技术测定人血中瑞芬太尼浓度变化,计算瑞芬太尼靶控输注时群体药代动力学参数并分析其药代动力学特点。结果国产瑞芬太尼血药浓度-时间变化符合二房室模型,分布半衰期为(16?.3±4.1) min,消除半衰期为(25.0±11.3) min,表观分布容积(70±12)L。结论国产瑞芬太尼海南地区群体药代动力学的变化规律与国外研究结果存在明显不同,有其特异性。
Related Articles
No related articles found