The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Study of Temperature Sensitive Nano Drug Delivery System Based on Hyaluronic Acid
Author(s): 
Pages: 1294-1299
Year: Issue:  12
Journal: Journal of Food Science and Biotechnology

Keyword:  hyaluronic acidnanoparticletemperature sensitivitypluronictargeting;
Abstract: 通过“Click”反应连接透明质酸与普朗尼克F127,制备两亲性材料(HA-F127),其结构通过1H NMR确认,接枝率为13%.材料在水溶液中可自组装形成纳米粒子,并能够包载抗肿瘤模型药物阿霉素.体外药物释放实验显示,其具有温度敏感释药特性.透明质酸可识别肿瘤细胞外过度表达的CD44受体,纳米粒子可靶向传递药物进入肿瘤细胞,且表现出良好的治疗效果.
Related Articles
loading...