Novel Synthesis Method of Cycloxaprid
Author(s): ZHANG Hong-yu, WU Qing-yang, ZHANG Zhi-ping, BI Qiang, DONG Jian-sheng, SHI Shun-fa, YE Zhen-jun
Pages: 21-24
Year: 2014 Issue: 6
Journal: World Pesticides
Keyword: cycloxaprid; succindialdehyde; synthesis;
Abstract: A novel synthetic route of cycloxaprid was developed. Using 1,1-dichloro-2-nitroethene as the starting material, 1,1-dimethoxy-2-nitroethene was obtainedvia nitration reaction. Followed by cyclization and condensation, the key intermediate 2-chloro-5-chloromethylpyridine (CCMP) was formed. The target compound was synthesized by reacting with CCMP and succindialdehyde. The new synthetic process had advantages of readily available raw materials, simple operations, mild reaction conditions. And the purity of the product was 97%. It was valuable to be used in industrial scale.
Pages: 21-24
Year: 2014 Issue: 6
Journal: World Pesticides
Keyword: cycloxaprid; succindialdehyde; synthesis;
Abstract: A novel synthetic route of cycloxaprid was developed. Using 1,1-dichloro-2-nitroethene as the starting material, 1,1-dimethoxy-2-nitroethene was obtainedvia nitration reaction. Followed by cyclization and condensation, the key intermediate 2-chloro-5-chloromethylpyridine (CCMP) was formed. The target compound was synthesized by reacting with CCMP and succindialdehyde. The new synthetic process had advantages of readily available raw materials, simple operations, mild reaction conditions. And the purity of the product was 97%. It was valuable to be used in industrial scale.
Related Articles