Progress of the Recovery Mechanism of Brain Injury Associated with the Gene Polymorphism of Apolipoproteins E
Author(s): YOU Yue, LI Ru-bo
Pages: 466-469
Year: 2014 Issue: 6
Journal: Journal of Forensic Medicine
Keyword: forensic pathology; craniocerebral traum a; review [publication type]; polym orphism; genetic; apolipoproteins E;
Abstract: Brain injury is a kind of wound by violence on head, which is a mechanical distortion of skull, meninx, cerebral vascular and brain tissue due to outside force acting on head. Apolipoproteins E (ApoE ) is a major kind of apolipoprotein s, participating in the metabolismof lipid and regulating bal-ance of cholesterol. Some recent investigations showthat gene polymorphismof ApoE is associated with various kinds of diseases. Also its immunoreactivity is changed regularly with brain injury. In addition, ApoE has remarkable effect in neurological normal growth and reparative process after brain injury. This article reviews the biological characteristics and mechanismof ApoE in the repair of brain injury and application prospect in forensic medicine, which may be able to provide newideas for estimation of the brain injury time and related experimental research.
Pages: 466-469
Year: 2014 Issue: 6
Journal: Journal of Forensic Medicine
Keyword: forensic pathology; craniocerebral traum a; review [publication type]; polym orphism; genetic; apolipoproteins E;
Abstract: Brain injury is a kind of wound by violence on head, which is a mechanical distortion of skull, meninx, cerebral vascular and brain tissue due to outside force acting on head. Apolipoproteins E (ApoE ) is a major kind of apolipoprotein s, participating in the metabolismof lipid and regulating bal-ance of cholesterol. Some recent investigations showthat gene polymorphismof ApoE is associated with various kinds of diseases. Also its immunoreactivity is changed regularly with brain injury. In addition, ApoE has remarkable effect in neurological normal growth and reparative process after brain injury. This article reviews the biological characteristics and mechanismof ApoE in the repair of brain injury and application prospect in forensic medicine, which may be able to provide newideas for estimation of the brain injury time and related experimental research.
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