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The Relations between Mild Impared Cognitive and Nocturnal Diastolic Blood Pressure Load in the Very Elderly with Hypertension
Pages: 1447-1449
Year: Issue:  12
Journal: Research of Traditional Chinese Medicine

Keyword:  hypertensionvery elderlyambulatory blood pressure monitoringcognition;
Abstract: Objective To analyze the relations between cognitive dsyfunction and ambulatory blood pressure parameters in the long term adherence to antihypertensive treatment of the very elderly with hypertension.Methods Sixty very elderly patients with hypertension were observed by 24 h ambulatory blood pressure.The cognitive function were evaluated by mini mental state examina-tion.According to MMSE scores,the patients were divided into two groups:Mild impaired cognitive groups(n = 27),normal cognitive function group(n = 33).The blood pressure parameters and biochemical indicators were observed.Results The education years in mild impaired cognitive group was(4.29± 5.38)years,which was less than that in normal cognitive function group[(8.39± 4. 19)years,P < 0.05].The nocturnal diastolic blood pressure load was(18.36±21.28)% in mild impared cognitive group,while was higher than that in normal cognitive function group [(4.04± 8.75)%,P < 0.05].The Spearman correlation test showed that the education year and cognitive function was positively correlated(r = 0.543,P = 0.003).The nocturnal diastolic blood pressure load exists signifi-cant negative correlation with cognitive function(r =- 0.404,P = 0.013).Conclusion To the long term adherence to antihyperten-sive treatment of the very elderly with hypertension,the education years and nocturnal diastolic blood pressure has close ties to mild impaired cognitive.The diastolic blood pressure at night may be a risk factor for cognitive dysfunction.The better control of nocturnal diastolic blood pressure may be one of the ways to prevent the elderly cognitive dysfunction.
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