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The Effect of High-fat Diet on Serum Lipid Parameters and Electrolyte Values in Mongolian Gerbils
Pages: 33-36
Year: Issue:  11
Journal: Guangdong Trace Elements Science

Keyword:  Mongolian gerbilsserumlipid parameterselectrolyte values;
Abstract: Objective To observe the effect of a high-fat diet on serum lipid parameters and electrolyte values of K+,Na+,Cl-,Ca2 +,Mg2 +in Mongolian gerbils. Methods Forty male Mongolian gerbils were selected and divided randomly into two groups( 20 each group). The first group of Mongolian gerbils were fed with a normal animal feed,while the second group were given a high-fat diet enriched with 1% cholesterol and 10% lard for twelve weeks. The serum samples were collected and tested for total cholesterol( TC),triglycerides( TG),high density lipoprotein cholesterol( HDL-C),low density lipoprotein cholesterol( LDL-C),and Ca2 +,Mg2 +values using Hitachi 7180 auto-analyser,and for serum values of K+、Na+、Cl-using Easy Lyte Plus electrolyte analyzer. Results Compared with normal animal feed group,the dietary intake of enriched with 1% cholesterol and 10% lard significantly increased the level of TC,TG,HLDL-C and LDL-C in the serum of Mongolian gerbils( P < 0. 01),and the serum level of TC and LDL-C were elevated remarkably. Meanwhile,the serum electrolyte K+and Mg2 +values were also significantly increased( P < 0. 01 and P < 0. 05),while there were no significant difference in electrolyte Na+、 Cl-、 Ca2 +values between both gerbils( P > 0. 05).Conclusion High-fat diet could significantly promote serum lipid parameters,and improve serum electrolyte K+、Mg2 +values in Mongolian gerbils.
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