Multi-center clinical study of Compound Wuzhigan Capsule in treatment of acute gastroenteritis
Author(s): SUN Hong, HU Hai-tang, CAO Hui, CHEN Xiao-mei, XU Rui, HUANG Wen-hua, HU Ya-jing, HUANG Xiao-min, Preclinical & Clinical Center, Livzon Pharmaceutical Group Inc., National Engineering Research Center for Modernization of TCM, Limin Pharmaceutical Factory, Livzon Pharmaceutical Group, The First Hospital Affiliated to Zhejiang University of TCM
Pages: 1257-1261
Year: 2014 Issue: 11
Journal: World Phytomedicines
Keyword: Compound Wuzhigan Capsule; Compound Wuzhigan Tablet; acute gastroenteritis; comprehensive efficacy;
Abstract: Objective To observe the curative effect and safety of Compound Wuzhigan Capsule in treatment of acute gastroenteritis. Methods A multi-center randomized double-blind positive parallel controlled trial method was adopted. The patients(120 cases) in the treatment group were po administered with Compound Wuzhigan Capsule, 2 grains/time, three times daily. The patients(120 cases) in the control group were po administered with Compound Wuzhigan Tablet, 4 tablets/time, three times daily. The clinical comprehensive efficacy, efficacy of TCM syndrome, and efficacy of single syndromes in two groups were observed. Results After treatment, the clinical comprehensive efficacies in the treatment and control groups were 98.32% and 98.31%, respectively, with no difference between the two groups. The efficacies of TCM syndrome in two groups were 98.32% and 98.31%, respectively, with no difference between the two groups. Two groups could significantly improve the change of defecate frequency and nature, abnormal defecate, abdominal distension painful, nausea, and vomiting, with no difference between the two groups. Conclusion Compound Wuzhigan Capsule has good clinical effect in treatment of acute gastroenteritis with good security.
Pages: 1257-1261
Year: 2014 Issue: 11
Journal: World Phytomedicines
Keyword: Compound Wuzhigan Capsule; Compound Wuzhigan Tablet; acute gastroenteritis; comprehensive efficacy;
Abstract: Objective To observe the curative effect and safety of Compound Wuzhigan Capsule in treatment of acute gastroenteritis. Methods A multi-center randomized double-blind positive parallel controlled trial method was adopted. The patients(120 cases) in the treatment group were po administered with Compound Wuzhigan Capsule, 2 grains/time, three times daily. The patients(120 cases) in the control group were po administered with Compound Wuzhigan Tablet, 4 tablets/time, three times daily. The clinical comprehensive efficacy, efficacy of TCM syndrome, and efficacy of single syndromes in two groups were observed. Results After treatment, the clinical comprehensive efficacies in the treatment and control groups were 98.32% and 98.31%, respectively, with no difference between the two groups. The efficacies of TCM syndrome in two groups were 98.32% and 98.31%, respectively, with no difference between the two groups. Two groups could significantly improve the change of defecate frequency and nature, abnormal defecate, abdominal distension painful, nausea, and vomiting, with no difference between the two groups. Conclusion Compound Wuzhigan Capsule has good clinical effect in treatment of acute gastroenteritis with good security.
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