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Nerve baby-sitter in reverse end-to-side neurorrhaphy preserves the structure of denervated muscle in rats
Author(s): 
Pages: 756-759
Year: Issue:  5
Journal: Journal of Peking University(Health Sciences)

Keyword:  DenervationAtrophymuscleNerve regenerationNeurorrhaphy;
Abstract: 目的:感觉神经寄养可以延缓失神经骨骼肌的萎缩,但传统的端端缝合寄养方式需切断供体神经远端而影响再生神经长入.本研究探讨反式端侧缝合寄养对大鼠失神经骨骼肌的保护作用.方法:雌性SD大鼠12只,随机分为反式端侧缝合组(n=6)和对照组(n=6).切断胫神经,缝扎近端、远端断端.反式端侧缝合组切断腓肠神经,在靠近胫神经进入腓肠肌的胫神经外膜上开窗,腓肠神经近断端以反式端侧缝合于胫神经开窗处.对照组只结扎胫神经近、远端断端.术后12周测量腓肠肌湿重、肌纤维横截面积、运动终板周径.结果:反式端侧缝合组腓肠肌湿重恢复率(39.2%±6.8%)明显优于对照组(19.5%±4.3%),差异有统计学意义(P<0.05).光镜下对照组腓肠肌大面积萎缩,周围明显纤维化;反式端侧缝合组腓肠肌萎缩不明显,肌纤维结构排列紧密完整,周围少量纤维化.反式端侧缝合组腓肠肌的平均横截面积、运动终板平均周径均显著大于对照组[(1 148.85 ±547.18)μm2 vs.(575.05±140.51) μm2,(102.84±53.29) μm vs.(59.60 ±26.71) μm],两组差异有统计学意义(P<0.05).结论:感觉神经反式端侧缝合寄养可以保护大鼠失神经骨骼肌的结构.
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