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Multiple effect of simvastatin on vascular endothelium of hypercholesterolemia patients
Author(s): 
Pages: 703-706
Year: Issue:  5
Journal: Journal of Peking University(Health Sciences)

Keyword:  HypercholesterolemiaSimvastatinAnkle brachial indexEndothelium vascularMonocyte chemoattractant proteins;
Abstract: 目的:观察降血脂药物辛伐他汀对未合并冠心病的高胆固醇血症患者踝臂指数(ankle brachial index,ABI)、肱动脉血管内皮血流介导的舒张功能(flow-mediated dilation,FMD)、肱动脉血管内皮硝酸甘油介导的舒张功能(nitroglycerin-mediated dilation,NMD)和血浆单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)水平的影响.方法:51例高胆固醇血症患者应用辛伐他汀20 mg/d,治疗12周,同时选取30例未接受辛伐他汀治疗的高胆固醇血症患者作对照组,分别在治疗开始前,治疗12周时测定患者的代谢指标、ABI、彩色多普勒超声检测FMD、NMD和MCP-1水平.结果:辛伐他汀治疗后,患者血浆总胆固醇(total cholesterol,TC)和低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)水平均明显降低,分别由原来的(6.06±1.03) mmol/L、(3.60±0.82) mmol/L降低为(4.98±1.34) mmol/L、(3.41 ±0.10) mmol/L(P <0.01,P<0.05);与治疗前相比,治疗后双侧ABI水平均显著升高,分别由原来的右侧ABI(ABIR) 1.11 ±0.06、左侧ABI(ABIL) 1.12 ±0.06升高至ABIR1.19 ±0.07、ABIL 1.19 ±0.10(双侧P均<0.01),FMD由治疗前的7.75%±11.30%,升高至治疗后的14.20%±15.39% (P <0.05),血浆MCP-1水平由原来的(112.0±7.8)ng/L降低至(108.9±6.2)ng/L(P<0.05),而对照组上述诸项前后变化不明显.结论:辛伐他汀可改善无明确冠心病的高胆固醇血症患者踝臂指数、肱动脉血管内皮血流介导的舒张功能和血浆单核细胞趋化蛋白-1水平.
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