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The path toward prognostication and prediction in stage Ⅱ colon cancer
Pages: 51-58
Year: Issue:  4
Journal: Engineering Sciences

Keyword:  colon cancerstageⅡstageⅢmicrosatellite instabilityLOH18qmulti-gene;
Abstract: Currently,there are several newer biomarkers that may be clinically useful in colon cancer. This paper focuses on a few of these biomarkers,namely microsatellite instability,loss of heterozygosity at chromosome 18q(LOH18q) and multi-gene assays,and discusses the clinical evidence behind their predictive or prognostic abilities. The results show that although there have been several newer prognostic factors identified,such as LOH18 q and multi-gene assays,none of these factors can predict benefit from treatment. Therefore,ongoing prospective clinical trials are still needed to further assess the role and optimal use of these tests.
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