Preparation of Micro-scale Particulates of Pioglitazone Hydrochloride by Rapid Precipitation without Surfactants
Author(s): YU Shi-hua, CHEN Ping, CHENG Zhen-yu, LIAN Li-li
Pages: 14-16
Year: 2014 Issue: 10
Journal: Technology & Development of Chemical Industry
Keyword: PH; rapid precipitation; micro-scale particulates;
Abstract: The microsized pioglitazone hydrochloride(PH) was prepared via the rapid precipitation proces without surfactant. The microsized pioglitazone hydrochloride and the raw drug were well characterized by scanning electron microscopy (SEM), powder X-ray diffraction (XRD), fourier transform infrared spectrometry (FT-IR). The study indicated that after micronization, the particle size decreased, the range of particle size distribution became well through SEM. FT-IR and XRD analysis indicated the particle size decreased and ccrystallinity decreased during the process and no change in chemical group structure.
Pages: 14-16
Year: 2014 Issue: 10
Journal: Technology & Development of Chemical Industry
Keyword: PH; rapid precipitation; micro-scale particulates;
Abstract: The microsized pioglitazone hydrochloride(PH) was prepared via the rapid precipitation proces without surfactant. The microsized pioglitazone hydrochloride and the raw drug were well characterized by scanning electron microscopy (SEM), powder X-ray diffraction (XRD), fourier transform infrared spectrometry (FT-IR). The study indicated that after micronization, the particle size decreased, the range of particle size distribution became well through SEM. FT-IR and XRD analysis indicated the particle size decreased and ccrystallinity decreased during the process and no change in chemical group structure.
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