Author(s): ZHANG Yi, YANG Li-na, CHEN Yi-feng, Dept. of Cardiothoracic Surgery, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Dept. of Pharmacy, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University
Pages: 930-932
Year: 2014 Issue:  10
Journal: Evaluation and Analysis of Drug-Use in Hospital of China
Keyword:  Cardiac valve replacement; Warfarin; Anticoagulant therapy; Prothrombin time; International normalized ratio;
Abstract: OBJECTIVE: To evaluate the safety of warfarin anticoagulation therapy and the importance of pharmaceutical care for patients after undergoing mechanical heart valve replacement surgery. METHODS: The clinical data of a total of 298 patients receiving warfarin anticoagulation therapy after undergoing heart valve replacement surgery from October 2007 to October 2012 in Zhangzhou Municipal Hospital Affiliated to Fujian Medical University( "our hospital") were retrospectively analyzed; the patients were observed followed-up with their prothrombin time( PT) and international normalized ratio( INR) and adverse drug reactions recorded. RESULTS: There were one case of skin purpura and 2 cases of death after operation. During the follow-up period,skin purpura occurred in one case,miscarriage in early pregnancy in one case,anemia caused by excessive menstrual flow during menstrual period in 4cases,bleeding after tooth extraction in 2 cases,brain infarction in one case and hemorrhage in 12 cases,all were cured or improved. CONCLUSIONS: Taking warfarin anticoagulation therapy correctly after undergoing mechanical heart valve replacement surgery plus a range of pharmaceutical care can significantly reduce the incidence of adverse drug reactions thereby ensuring the safety of anticoagulation therapy.