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Physiological and Pathological Effects of miR-23a and miR-27a in Ovary
Pages: 367-369
Year: Issue:  5
Journal: Foreign Medical Sciences(Family Planning/Reproductive Health Fascicle)

Keyword:  MicroRNAsFollicleOvaryPremature ovarian failureOvarian neoplasms;
Abstract: MicroRNAs(miRNAs) play important roles in many cellular events,such as proliferation,differentiation,apoptosis,survive and tumorigenesis by regulating expression of target genes at posttranscriptional level. Many miRNAs have been found in ovary, including miR-23 a and miR-27 a. miR-23 a and miR-27 a are members of the miR-23 a ~27a ~24-2 super-family,induce apoptosis via caspase-dependent or caspase-independent pathways and endoplasmic reticulum stress. It was found that miR-23 a and miR-27 a were involved in many ovarian function and pathophysiology,including follicular development,hormone synthesis and secretion,premature ovarian failure and ovarian cancer. Many effects of miRNAs in ovarian function have been elucidated,which is helpful for new treatment options for sterility and other ovarian diseases. The functions of miR-23 a and miR-27 a in ovary were reviewed in this paper.
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