GPC3 plus alpha fetoprotein versus alpha fetoprotein alone in the diagnosis of hepatocellular carcinoma : a meta-analysis
Author(s): YU Chao, HUANG Zaozao, YANG Shengli, SUN Chengyi, JIANG Jianxin, LIU Ping, WU Chao, HE Qianjin, YAO Hongyi
Pages: 566-571
Year: 2014 Issue: 8
Journal: Chinese Journal of Hepatobiliary Surgery
Keyword: Glypican-3; Alpha-fetoprotein; Tumor marker; Liver cancer; Meta-analysis;
Abstract: Objective To investigate the diagnostic value of serum glypican-3 (GPC3) combined with alpha-fetoprotein (AFP) versus alpha fetoprotein alone for hepatocellular carcinoma.Methods A comprehensive electronic search and additional manual tracking were performed to retrieve published studies addressing the diagnostic value of GPC3 combined with AFP compared with AFP alone for liver cancer.The retrieved literatures were screened and selected according to pre-determined inclusion and exclusion criteria.Data were extracted and analyzed using the software STATA12.0.Summary receiver operating characteristic curves were used to compare test performance of the two.Results Nineteen studies met the inclusion criteria and were included into this study.Heterogeneity existed among these studies,but it was not possibly caused by the threshold effect.Therefore,we used the random effect model for quantitative analysis.The pooled accuracy indicator,sensitivity and specificity were 0.61 and 0.93 for AFP alone,and 0.84 and 0.86 for GPC3 combined with AFP,respectively.The area under summary receiver operating characteristics curve and Q index were 0.81 and 0.75 for AFP alone,and 0.91 and 0.85 for GPC3 combined with AFP.Conclusious GPC3 combined with AFP significantly improved the diagnostic sensitivity,and its specificity remained at a high level (0.86),indicating that the combined use of GPC3 and AFP is helpful for screening and early diagnosis of liver cancer.
Pages: 566-571
Year: 2014 Issue: 8
Journal: Chinese Journal of Hepatobiliary Surgery
Keyword: Glypican-3; Alpha-fetoprotein; Tumor marker; Liver cancer; Meta-analysis;
Abstract: Objective To investigate the diagnostic value of serum glypican-3 (GPC3) combined with alpha-fetoprotein (AFP) versus alpha fetoprotein alone for hepatocellular carcinoma.Methods A comprehensive electronic search and additional manual tracking were performed to retrieve published studies addressing the diagnostic value of GPC3 combined with AFP compared with AFP alone for liver cancer.The retrieved literatures were screened and selected according to pre-determined inclusion and exclusion criteria.Data were extracted and analyzed using the software STATA12.0.Summary receiver operating characteristic curves were used to compare test performance of the two.Results Nineteen studies met the inclusion criteria and were included into this study.Heterogeneity existed among these studies,but it was not possibly caused by the threshold effect.Therefore,we used the random effect model for quantitative analysis.The pooled accuracy indicator,sensitivity and specificity were 0.61 and 0.93 for AFP alone,and 0.84 and 0.86 for GPC3 combined with AFP,respectively.The area under summary receiver operating characteristics curve and Q index were 0.81 and 0.75 for AFP alone,and 0.91 and 0.85 for GPC3 combined with AFP.Conclusious GPC3 combined with AFP significantly improved the diagnostic sensitivity,and its specificity remained at a high level (0.86),indicating that the combined use of GPC3 and AFP is helpful for screening and early diagnosis of liver cancer.
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