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Clinical Effect of “Modified “Erxian Decoction”on Perimenopausal Hypertension of Predominant Yang due to Yin Deficiency Type
Pages: 38-41
Year: Issue:  4
Journal: Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai

Keyword:  hypertensionperimenopausal periodmodified"Erxian Decoction"predominant yang due to yin deficiency type;
Abstract: Objective: To observe the clinical effect of modified "Erxian Decoction"on perimenopausal hypertensive women of predominant yang due to yin deficiency type. Methods: Forty-eight patients of perimenopausal hypertension were randomly divided into treatment group( n = 25) and control group( n = 23). All the patients were treated with fosinopril,and the patients in treatment group were treated with modified"Erxian Decoction"in addition,with a course of four weeks. The scores of Chinese medical syndrome and the blood pressure were observed,and the levels of AngiotensinⅡ( AngⅡ),estradiol( E2),follicle-stimulating hormone( FSH) and luteinizing hormone( LH) were detected. Results: After treatment,the scores of Chinese medical syndrome in the treatment group were obviously decreased( P < 0. 05),and there was a statistical difference in both of the two groups in D-value of scores between before and after treatment( P < 0. 05); the levels of systolic blood pressure and diastolic blood pressure in both groups were significantly decreased( P < 0. 05),and the level of systolic blood pressure in treatment group was lower than that of the control group( P < 0. 05); the level of E2 in the treatment group was increased( P < 0. 05),and there was a statistical difference between the two groups on the D-value of the levels of AngⅡ,E2 and LH between before and after treatment( P < 0. 05). Conclusion: modifide"Erxian Decoction"can lower the blood pressure collaborated with fosinopril,decrease the level of E2 and improve the Chinese medical syndrome in perimenopausal hypertensive women.
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