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Effects of “Yunnan Dengzhanhua Capsule”on Renal Function and Expressions of Tumor Growth Factor-β1 and Plasminogen Activator Inhibitor-1 in Rats with Chronic Renal Failure
Author(s): 
Pages: 70-73
Year: Issue:  4
Journal: Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai

Keyword:  "Yunnan Dengzhanhua Capsule"chronic renal failure(CRF)renal fibrosisplasminogen activator inhibitor-1tumor growth factor-β1;
Abstract: Objective: To study the effects of"Yunnan Dengzhanhua Capsule"on renal function and renal fibrosis in rats with chronic renal failure( CRF). Methods: Sixty SD rats were randomly divided into normal control group,model group,Benazepril group and"Yunnan Dengzhanhua Capsule"group,with 15 rats in each group. The CRF models were established by5 /6 nephrectomized. The Benazepril group was treated with Benazepril( 0. 29 mg /100 g) by intragastric administration. The"Yunnan Dengzhanhua Capsule"group was treated with"Yunnan Dengzhanhua Capsule"( 0.3 g/100 g) intragastrically. The normal control group and model group were treated with the same dose of normal saline( NS) intragastrically,with the course of 12 weeks. We detected the serum creatinine( Scr),blood urea nitrogen,24 h urinary protein before and after treatment.Expressions of TGF-β1and PAI-1 were determined by RT-PCR method after treatment. Results: Compared with the model group,the serum creatinine( Scr),blood urea nitrogen and 24 h urinary protein in the"Yunnan Dengzhanhua Capsule"group and Benazepril group were decreased markedly( P < 0. 05),and the Scr and 24 h urinary protein in the"Yunnan Dengzhanhua Capsule"group were lower than that of the Benazepril group( P < 0. 05). Expressions of TGF-β1and PAI-1 in the"Yunnan Dengzhanhua Capsule"group and Benazepril group were lower than that of the model group,with significant difference between them( P < 0. 05),and the expressions of TGF-β1and PAI in the"Yunnan Dengzhanhua Capsule"group were lower than that of the Benazepril group( P < 0. 05). Conclusion: "Yunnan Dengzhanhua Capsule"can improve renal function and inhibit renal fibrosis in CRF rats.
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