Progress on the Techniques for Enhancing Aqueous Solubility of Water Insoluble Drugs for Parenteral Delivery
Author(s): WANG Ju-fen, WU Xu-ri, CHEN Yi-jun, Laboratory of Chemical Biology, China Pharmaceutical University
Pages: 253-259
Year: 2014 Issue: 3
Journal: Pharmaceutical Biotechnology
Keyword: Poorly water soluble drugs; Solubility enhancement; Parenteral formulation; Co-solvent; pH; Hydrotrophy; Nanosuspen-sion;
Abstract: Water insolubility is the primary cause for over 40% of failures of drug development,including postponement,or complete termination. Novel drug development,even much-needed reformulation of currently marketed products,can be significantly affected by these challenges. Water solubility is a major issue for injectable formulations. Currently,various approaches,such as pH adjustment,salt formation,co-solvency,have been employed to enhance the solubility of poorly water soluble drugs. However,each strategy exhibits certain advantages and limitations during the pharmaceutical product development. More advanced techniques including nano-suspension,supercritical processing may provide greater opportunities in the preparation of poorly soluble drugs for parenteral delivery systems. The present review is devoted to various techniques for enhancing water solubility of parenteral delivery systems in order to reduce the percentage of poorly water soluble drug candidates eliminated from the development.
Pages: 253-259
Year: 2014 Issue: 3
Journal: Pharmaceutical Biotechnology
Keyword: Poorly water soluble drugs; Solubility enhancement; Parenteral formulation; Co-solvent; pH; Hydrotrophy; Nanosuspen-sion;
Abstract: Water insolubility is the primary cause for over 40% of failures of drug development,including postponement,or complete termination. Novel drug development,even much-needed reformulation of currently marketed products,can be significantly affected by these challenges. Water solubility is a major issue for injectable formulations. Currently,various approaches,such as pH adjustment,salt formation,co-solvency,have been employed to enhance the solubility of poorly water soluble drugs. However,each strategy exhibits certain advantages and limitations during the pharmaceutical product development. More advanced techniques including nano-suspension,supercritical processing may provide greater opportunities in the preparation of poorly soluble drugs for parenteral delivery systems. The present review is devoted to various techniques for enhancing water solubility of parenteral delivery systems in order to reduce the percentage of poorly water soluble drug candidates eliminated from the development.
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