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Advances in 5-hydroxytryptamine and its receptors in insects
Pages: 844-859
Year: Issue:  7
Journal: Acta Entomologica Sinica

Keyword:  Insectsneuronbiogenic amine5-hydroxytryptamine(5-HT)G protein-coupled receptorspharmacology;
Abstract: 5-Hydroxytryptamine( 5-HT) is an important biogenic amine in insects,which is synthesized in both neuronal and peripheral tissues and can be reuptaken by serotonin transporter into presynaptic neuron. 5-HT plays various important physiological roles in insects through specific G protein-coupled receptors,such as feeding,circadian behavior,aggregation,learning and memory. There are five types of 5-HT receptors in insects,i. e.,5-HT1 A,5-HT1 B,5-HT2 A,5-HT2 Band 5-HT7. 5-HT1 Aand 5-HT1 B inhibit intracellular cAMP production,5-HT2 Aand 5-HT2 Bincrease Ca2 +level,and 5-HT7 induces cAMP production. In recent years,great progress has been made in the research of 5-HT in insects,especially their receptors. More and more 5-HT receptor genes have been cloned, and their functions and pharmacological properties have been analyzed. The pharmacological differences of 5-HT receptors from different insects will provide fundamental basis for designing and developing new specific insecticides for pest management.
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