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Correlation between the hypoxia inducible factor-1αPro582Ser polymorphism and type 2 diabetic nephropathy
Pages: 2078-2080
Year: Issue:  13
Journal: The Journal of Practical Medicine

Keyword:  Diabetic nephropathyHypoxia-inducible factor-1αPolymorphism;
Abstract: Objective To explore the relationship between the hypoxia-inducible factor-1α (HIF-1α) Pro582Ser polymorphism and type 2 diabetic nephropathy (DN). Methods Two hundred and forty four subjects with type 2 diabetes were recruited. HIF-1α Pro582Ser polymorphism was detected using PCR-RFLP to analyses. Results SNPs were detected at the site of 1 285 bp of HIF-1α exon , which could turn proline to serine (Pro582Ser). T allele carrying rate was significantly higher in the patients with DN than in those with right diabetes (P<0.05) at 1 285 bp site of HIF-1αexon. By Logistic regression analysis, high HbA1c and low HDL-c were risk factors for DN and Pro582Ser was excluded in the equation. Conclusion High HbA1c and low HDL-c are risk factors for type 2 DN. HIF-1αPro582Ser SNPs may be correlated with type 2 DN, but the correlation needs further exploration.
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