Author(s): LIU Fei-fei, WANG Jian-jun, SHEN Qin, YU Bo, LU Zhen-feng, MA Heng-hui, SHI Qun-li, Department of Pathology, Nanjing University School of Medicine/Nanjing General Hospital of Nanjing Military Region
Pages: 435-438
Year: 2014 Issue:  5
Journal: National Journal of Andrology
Keyword:  testis; yolk sac tumor; endodermal sinus tumor; immunohistochemistry;
Abstract: Objective: To investigate the clinicopathological characteristics,diagnosis and treatment of primary testicular yolk sac tumor( YST). Methods: We studied 8 cases of primary testicular YST by microscopy and immunohistochemistry. Results: The 8 cases of primary testicular YST,including 2 consultation cases,were confirmed from 1998 to 2013,accounting for 10. 7%( 8/75) of all the testicular germ cell tumors diagnosed in our hospital. The patients ranged in age from 7 to 43 years,23. 9 years on average. The main clinical manifestation of the patients was painless unilateral testis swelling. Microscopically,reticular tissues, schiller-duvaI( S-D) bodies,and eosin-stain transparent bodies were seen in the tumors. One of the cases was confirmed to be simple YST,while the other 7 mixed YST. AFP was a characteristic immunophenotype marker of the tumors. Conclusion: Primary testicular YST is a rare malignancyr with poor prognosis. Its diagnosis depends on preoperative AFP test and postoperative pathology. Comprehensive treatment,including orchiectomy,chemotherapy,and radiotherapy,can prolong the survival of the patients.