Author(s): HAN Xuelian, Jiangsu Research Institute of Safety Production Science
Pages: 1526-1532
Year: 2014 Issue:  6
Journal: Chemical Industry and Engineering Progress
Keyword:  resveratrol; derivatives; analogues; anti-tumor activity; mechanism;
Abstract: Resveratrol has extensive biological activities,especially its anti-tumor effect,so its pharmacological properties have been studied. At the same time, in order to improve the bioavailability,and obtain a higher antitumor activity,studies on their derivatives and analogues have been widely carried out. In this paper,the items of chemical structure,physical and chemical properties,antitumor mechanism,genetic toxicity,kinetics of resveratrol and the antitumor activity and mechanism of resveratrol derivatives and analogues were reviewed. There are still many needs to continue to study in this area. Its biological mechanism of action,relationship between structure and activity,bioavailability and efficacy,and pharmacokinetics studies need to be further investigated. As a new promising anticancer drug, a systematic study on its effect mechanism, toxicology, pharmacokinetics,animal experiment of resveratrol,its derivatives and analogues need to be carried out.