Author(s): WANG Tian-zi, LIU Yan-yan, DONG Chun-liu, YAN Ming, CHEN Jian-qing, SHENG Zun-lai, LI Yan-hua, Department of Animal Pharmacy, College of Veterinary Medicine, Northeast Agricultural University
Pages: 545-550
Year: 2014 Issue:  5
Journal: Chinese Veterinary Science
Keyword:  praziquantel; solid dispersion; polyethylene glycol 4000(PEG 4000); poloxamer 188(P 188); solvent evaporation method;
Abstract: Praziquantel solid dispersions were prepared by the solvent evaporation method of polyethylene glycol 4000(PEG 4000)and poloxamer 188(P 188).Dissolution profiles were investigated by the effects of the proportion of drug and carrier on drug release.X-ray diffraction,fourier transform infrared spectroscopy,and scanning electron microscopy were conducted separately for evaluating the status of the praziquantel in solid dispersions.The praziquantel in solid dispersions existed in the form of amorphous state.The drug release varied from the different ratios of carriers or drug-carrier in solid dispersion.The best ratio of praziquantel to a joint carrier in solid dispersion was 1∶5in mass ratio(PEG 4000∶P 188= 3∶1in mass ratio)and the solid dispersions in vitro reached 100%.The praziquantel solid dispersions in vitro was improve by solvent evaporation method of PEG 4000and P 188.