Author(s): HU Jian-hua, LIU Feng, LI Hong-jian, YANG Zhao, LIU Wei, ZHANG Chao, Department of orthopedics, The first people’s Hospital of Yunnan Province, Department of orthopedics, Kunming children’s Hospital of Yunnan Province
Pages: 1243-1246
Year: 2014 Issue:  7
Journal: Biomagnetism
Keyword:  Bisphostates; Osteolysis; Revision; Osteointegration;
Abstract: Objective: To evaluate the alendronate New Zealand white rabbits of periprosthetic osteolysis, renovated New Zealand white rabbits prosthesis osseointegration. Methods: 30 selected male New Zealand white rabbits were randomly divided into three groups(normal control group, the experimental group, the control group, n = 10).Area of the normal group tibia cancellous bone implanted titanium prosthesis, the experimental and control groups were implanted with a titanium prosthesis and titanium particles 8 weeks, three groups of reunification of the renovation of the prosthesis. Sacrificed after 8 weeks of treatment in the experimental group with alendronate control group and normal group were drawn renovated. Through the the prosthesis launch mechanics experimental hard tissue slice observation, evaluation of the effects of alendronate on periprosthetic renovated osseointegration. Resluts: Prosthesis launched mechanics experimental.Results: Show that the experimental group(alendronate treatment group) prosthesis launched load was significantly greater than the control group(P<0.01). Hard histological sections through of picric- Magenta staining using image analysis instrument Statistics periprosthetic osseointegration periprosthetic bone area of the experimental group was significantly better than the control group periprosthetic bone mass(P<0.05). Conclusion: Bisphosphonates-alendronate the periprosthetic bone integration can improve the prosthesis renovated.