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The effect of cytokines in the bone microenvironment on bone metastasis of breast cancer
Author(s): 
Pages: 207-210,211
Year: Issue:  3
Journal: Journal of Nantong University(Medical sciences)

Keyword:  breast cancerbone metastasisbone microenvironmentcytokine;
Abstract: Breast cancers preferentially metastasize to bone, which generally cause osteolytic and osteoblastic lesions. The crosstalk between metastatic breast cancer cells and bone microenvironment plays a central role in the development and pro-gression of bone metastases. Bone is rich in cell types and cytokine that make it a predominant environment for breast cancer cells growth. Once breast cancer cells enter the bone microenvironment,they can secrete factors that act on bone cells and contribute to the bone destruction.
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