Author(s): LI Gang, LU Weihua, FANG Qing, CHENG Jian, ZENG Xianmei, FANG Ping, ZHOU Zihua, LIAO Yuhua, Department of Cardiology, Union Hospital, Huazhong University of Science and Technology, Department of Emergency, Wuhan General Hospital of Guangzhou Military
Pages: 258-262
Year: 2014 Issue:  3
Journal: Journal of Clinical Cardiology
Keyword:  diabetes; coronary artery calcification progression; gamma-glutamyltransferase;
Abstract: Objective:To determine whether serum gamma-glutamyltransferase(GGT)levels can independtly predict the progression of coronary artery calcification(CAC)in adults with type 2 diabetes.Method:A total of 326 type 2 diabetic patients asymptomatic of cardiovascular disease were evaluated by CAC imaging.Risk factors and GGT levels were measured.CAC scores were assessed by 320-slice CT scanner at baseline and(20±4)months of follow-up.Result:A total of 172 patients(52.8%)showed varying degrees of CAC.GGT levels were higher in progressors than in non-progressors[(39.0±15.6)U/L vs(27.0±10.8)U/L,P<0.001].In multivariable analyses,GGT retained a strong association with CAC progression after adjustment for age,gender,and other risk factors(OR=1.082,95%CI:1.051~1.114,P<0.01).Multivariate Cox proportional hazards model showed that age and LDL were significant predictors of early cardiovascular events.Conclusion:In asymptomatic patients with type 2diabetes,GGT has a positive correlation with baseline CAC and may be an independent predictor of CAC progression.