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Protection of Chuanxiong Jiuxin Dropping Pill on experimental myocardial ischemia in rats and mice
Author(s): 
Pages: 476-480
Year: Issue:  5
Journal: World Phytomedicines

Keyword:  Chuanxiong Jiuxin Dropping Pillexperimental myocardial ischemiainvigorating circulation of bloodanti-ischemia myocardialhypoxia toleranceprotection;
Abstract: Objective To evaluate the protective effects of Chuanxiong Jiuxin Dropping Pill on experimental myocardial ischemia in rats and mice using various experimental model. Methods The anti-myocardial ischemia effects of Chuanxiong Jiuxin Dropping Pill were observed using acute experimental myocardial ischemia model rats caused by coronary artery ligation of anterior descending branch. The effects of Chuanxiong Jiuxin Dropping Pill on invigorating the circulation of blood were observed using high blood viscosity model rats induced by intravenous injection of high molecular Dextran. The effects of Chuanxiong Jiuxin Dropping Pill on hypoxia tolerance were observed using the injection of isoproterenol experimental model. Results There was significant difference between the model group and 0.32, 0.64 g/kg Chuanxiong Jiuxin Dropping Pill groups in inhibiting the increase caused by the anterior descending coronary artery ligation induced standard II-lead electrocardiograph ST segment and reducing myocardial infarct size. The 0.16, 0.32, and 0.64 g/kg Chuanxiong Jiuxin Dropping Pill groups could significantly inhibit the increase of whole blood viscosity caused by high blood viscosity model induced by high molecular Dextran. There was significant difference between the model group and 0.46, 0.92 g/kg Chuanxiong Jiuxin Dropping Pill groups in prolonging the survival time of mice under normobaric hypoxia condition after the injection of isoprenaline. Conclusion Chuanxiong Jiuxin Dropping Pill has the obvious effect on invigorating the circulation of blood and hypoxia tolerance, and has a protective effect on experimental myocardial ischemia.
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