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Release of multi-components in GardeniaTotal Glycosides Sustained-release Tablets in vitro
Pages: 485-488
Year: Issue:  5
Journal: World Phytomedicines

Keyword:  GardeniaTotal Glycosides Sustained-release Tabletsgardenosidegenipingeniobiosidegeniposiderelease;
Abstract: Objective To explore the evaluation method for in vitro release of multi component in Gardenia Total Glycosides Sustained-release Tablets. Methods Rotating basket method was carried out to determine the release rate. HPLC method was employed to assess the release rate of gardenoside, genipingeniobioside, and geniposide, and UV method was used to determine the total glycosides. Results The release rates of gardenoside, genipingeniobioside, geniposide, and total glycosides were similar. Similarity factors were 81%, 72%, and 91%. The data of cumulative release rate fitted best with Higuchi model. The release of Gardenia Total Glycosides Sustained-release Tablets had a well-balanced release behavior. Conclusion Quality of multi-components in Gardenia Total Glycosides Sustained-release Tablets can be controlled effectively by the method.
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