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Research progress on glycosylation methods of rare ginsenosides
Author(s): 
Pages: 574-582
Year: Issue:  5
Journal: World Phytomedicines

Keyword:  rare ginsenosidesglycosylationchemical synthesisenzymolysismicrobial transformation;
Abstract: Rare ginsenosides, as a class of important active components of ginsenosides, have strongly potent antitumor effects. Glycosylation is the mainly method to synthesis them. There are three methods for glycosylation, namely chemical synthesis, enzymolysis, and microbial transformation. At the same time, studies have shown that glycosylation could change the biological activity, stability, water solubility, and the mutual recognition and binding property with receptor molecules. It can also reduce or eliminate the toxicity of endogenous and exogenous toxic substances. Three types of glycosylation methods have been summarized, and the pros and cons of each method have been compared and concluded, which help us choose the best glycosylation method for the synthesis of rare ginsenosides in order to meet the needs of clinical and scientific research. In this paper, the new progress on the glycosylation of rare ginsenosides are summarized, and the trends in the development of glycosylation of ginsenosides in the future are also briefly discussed.
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