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Optimization of prescription of Nimesulide Cream by orthogonal test
Pages: 481-484
Year: Issue:  5
Journal: World Phytomedicines

Keyword:  Nimesulide Creamprescription optimizationtransdermal absorptionorthogonal test;
Abstract: Objective To optimize the prescription of Nimesulide Cream. Methods LB9B(3P 4 P) orthogonal design was used to optimize the prescription of Nimesulide Cream. Azone, propylene glycol, and peregal O20 were selected as three factors, and each factor formed three levels. Permeation rates were determined with Franz diffusion device in isolated mouse abdominal skin as a barrier. Phosphate buffer(pH 7.4) was used as acceptable medium in(37 ± 1) ℃ water bath with speed of 500 r/min. Results Azone was the main factor affecting the rate of percutaneous absorption, and the following was peregal O20. The optimal conditions were determined by the experimental data, such as 3% azone, 15% propylene glycol, and 1% peregal O20. It could be conclude from the cumulative permeation quantity- time curve that transdermal absorption accorded with Zero order equation. Conclusion The prescription of Nimesulide Cream is reasonable, and the preparation technology is feasible.
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