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Clinical observation of Ambroxol Hydrochloride Injection in treatment of respiratory infection after tracheotomy of traumatic brain injury
Author(s): 
Pages: 516-519
Year: Issue:  5
Journal: World Phytomedicines

Keyword:  Ambroxol Hydrochloride Injectionbronchoalveolar lavagetraumatic brain injurytracheotomy;
Abstract: Objective To explore the efficacy of Ambroxol Hydrochloride Injection in treatment of respiratory infection after tracheotomy of traumatic brain injury. Methods Patients with tracheostomy(76 cases) after traumatic brain injury who came to Shuguang Hospital Affiliated to Shanghai University of TCM for treatment from April 2008 to December 2013 were randomly divided into treatment(38 cases) and control(38 cases) groups. The patients in the control group were received bronchoalveolar lavage. The patients in the treatment group were iv administered with Ambroxol Hydrochloride Injection 30 mg added into 18 mL saline, three times daily, each time interval of 8 h, and continuous used for 1 week. And the other treatment was the same as the control group. Respiratory tract infection and control situation of two groups were compared after tracheotomy. Results The leukocyte number in alveolar lavage of treatment group was obviously less than that of control group on days 5 and 7, and there were significant differences between the two groups(P < 0.05). The polymorphonuclear cell number in alveolar lavage of treatment group was obviously less than that of control group on the 3, 5, 7 d, and there were significant differences between the two groups(P < 0.05). One month after tracheostomy, incidence of respiratory infection in treatment and control groups were 60.5% and 92.1%, respectively, and there were significant differences between the two groups(P < 0.05). Infection control rate in treatment and control groups were 82.6% and 57.1%, and there were significant differences between the two groups(P < 0.05). Conclusion Ambroxol Hydrochloride Injection combined with bronchoalveolar lavage has a significant effect on respiratory infection with traumatic brain injury after tracheotomy, which is worth promoting.
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