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Comparative Study of Preventive and Therapeutic Effects Between Xenoestrogen and “Erxian Decoction”on Premature Ovarian Failure Induced by Tripterygium Glycosides in Rats
Author(s): 
Pages: 75-77
Year: Issue:  6
Journal: Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai

Keyword:  Estrogen"Erxian Decoction"premature overian failure(POF)tripterygium glycosidesorgan indexsexual hormone;
Abstract: Objective: To compare the preventive and therapeutic effects of exogenous estrogen and"Erxian Decoction"on premature overian failure( POF) induced by tripterygium glycosides in rats. Methods: Female SD rats were randomized into blank control group,model group,estrogen group and"Erxian Decoction"group. The models were established by tripterygium glycosides. The rats in blank control group and model group were treated with normal saline intragastrically,and rats in estrogen group and"Erxian Decoction"group were treated with estrogen and"Erxian Decoction"respectively intragastrically. After 21 days intervention,the coefficient of uterus,ovary and adrenal glands were detected and the levels of E 2,LH and FSH were detected by radioimmunoassay. Results: Exogenous estrogen can increase organ indexes of uterus,ovary and adrenal glands( P < 0. 05,P < 0. 01),and also can recover the E 2 level in rat with POF,but no significant changes was found in LH and FSH; the organ indexes of ovary and adrenal glands were increased in"Erxian Decoction"group( P < 0. 05,P < 0. 01), and no significant difference was found in uterus index and serum sexual hormone level. Conclusion: Exogenous estrogen has positive effects on POF,and its therapeutic effect is better than"Erxian Decoction".
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