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Effect of dexmedetomidine on hypoxic pulmonary vasoconstriction and oxygenation during one-lung ventilation
Author(s): 
Pages: 127-129
Year: Issue:  2
Journal: Modern Practical Medicine

Keyword:  右美托咪定单肺通气缺氧性肺血管收缩;
Abstract: 目的 探讨右美托咪定对单肺通气时缺氧性肺血管收缩及氧合的影响.方法 将40例择期行单肺通气下肺叶切除术的肺癌患者分为对照组和治疗组,各20例,记录患者一般临床资料,并分别于麻醉诱导前(T0)、侧卧位双肺通气(TLV)后10 min(T1)、单肺通气(OLV)后10 min (T2)、OLV后60min(T3)及侧卧位恢复TLV后10min(T4)行血气分析计算肺内分流率(Qs/Qt)及氧合指数.结果 两组患者手术时间及OLV时间差异均无统计学意义(均P>0.05);治疗组异丙酚的用量显著少于对照组,差异有统计学意义(P<0.05);治疗组在T2、T3时肺内分流率少于对照组,氧和指数明显增加,差异均有统计学意义(均P< 0.05).结论 右美托咪定可以缓解OLV时肺内分流、提高氧合,在一定程度上预防OLV时低氧血症的发生.
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