Author(s): TIAN Mei-mei, WANG Xian-bo, LI Yun-ru, QIAN Fang, ZHANG Yi-jin, DUAN Xue-fei, FAN Xiao-ling, Department General Medicine, Beijing Ditan Hospital, Capital Medical University
Pages: 5929-5933
Year: 2013 Issue:  30
Journal: Progress in Modern Biomedicine
Keyword:  Drug-induced liver injury; Clinical feature; Prognosis.;
Abstract: Objective: To investigate the clinical features and prognosis factors of patients with drug-induced liver failure(DILF)and to raise the awareness of drug-induced liver failure and reduce the probability of occurrence of adverse events. Methods: The clinical data of 56 DILF patients who were admitted to our hospital from Jan. 2007 to Dec. 2011 were reviewed, and the drug use, clinical manifestations, complications, biochemical factors, treatments and prognosis of those patients were analyzed. Results: The mainly 3 kinds of drugs causing DILF were herbal medicines(30.3%),anti-tuberculosis drugs(26.8%) and Non steroidal anti-inflammatory drugs(23.2%).The common clinical manifestations was fatigue(64.2%), anorexia(60.7%), yellow urine(60.7%). The 3 tops underlying complications were infection(73.2%), hepatic encephalopathy(66.1%), ascites(64.3%). Abdominal cavity and pulmonary was the main position of infection, 46.4%and 41% respectively. A total of 18 cases(26.2%) of the patients were cured and improved, 14 cases(25.0%) of the patients were invalid, and 24 cases(42.9%) of the patients were dead. From the time when the patients had clinical manifestations or the abnormal liver function to died, the medium time was 35 days. The rate of hepatic encephalopathy and gastrointestinal bleeding was much lower in the cured and improved group than that in the invalid and dead group. Treating DILF used glucocorticoids were significantly relative to the better prognosis(P<0.05). Conclusion: The drugs casing DILF mainly are herbal medicines, anti-tuberculosis drugs and analgesic drugs. The clinical features are not specific, hepatic encephalopathy and gastrointestinal bleeding are related to the bad prognosis. In the early phase of DILF, glucocorticoids use can significantly improve the prognosis.