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Research Progress of Circulating MicroRNAs and Breast Cancer
Author(s): LI Ya-nan, XING Han-ying, HAO Yu-bin
Pages: 249-
255
Year: 2014
Issue:
3
Journal: Chinese General Practice
Keyword: 乳腺肿瘤; 肿瘤标记; 生物学; 微小RNA;
Abstract: 微小RNA(miRNAs)是一类内源性非编码单链微小RNA,参与细胞增殖、分化、凋亡等多种生物学过程.近年来研究发现miRNAs可由细胞内释放到细胞外液,如血清、血浆、组织液及各类体液中,即循环miRNAs.在疾病状态下如乳腺癌,循环miRNAs表达谱发生改变,良好的稳定性及疾病相关性使得miRNAs成为肿瘤等疾病的非创伤性新型生物标志物,是肿瘤诊断与防治的研究热点.现就循环miRNAs与乳腺癌的相关研究进展做一综述.
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