Author(s): LIN Yongkai, HUANG Yuxin, LIANG Guihong, XIE Pingjin, ZHANG Tiancheng, LIANG Zujian, The Third Clinical College, Guangzhou University of Chinese Medicine, Orthopaedic Hospital Affiliated to Guangzhou University of Chinese Medicine
Pages: 137-140
Year: 2014 Issue:  2
Journal: Journal of Traditional Chinese Medicine
Keyword:  osteoporosis; depression; kidney-supplementing liver-regulating formula; alendronate sodium tablets;
Abstract: Objective To research the therapeutic effect of kidney-supplementing liver-regulating formula for primary osteoporosis associated with depression in elderly. Methods Eighty cases of primary osteoporosis,aged 75 to 95 years,associated with depression were randomized into the treatment group and control group,with 40 in each. The treatment group was given kidney-supplementing liver-regulating formula one dose daily. The control group was given 70mg alendronate sodium tablets once weekly. The therapeutic effect and antidepressant efficacy was evaluated after 4-week treatment. The depression scores were compared before and after 1-week,2-week,3-week and 4-week treatment in both groups. Results The total effective rate of the treatment group and control group was 87. 50% and 83. 87% respectively,with no significant difference between groups( P > 0. 05). The antidepressant efficacy in the treatment group and control group was 93. 75% and 83. 87% respectively,with a significant difference between groups( P < 0. 01). There were significant differences between before and after treatment in the depression scores in both groups( P < 0. 05),especially after 4-week treatment( P < 0. 05). Comparing with the control group,the depression scores in the treatment group were significantly decreased after 2-week,3-week and 4-week treatment( P < 0. 05). Conclusion Kidney-supplementing liver-regulating formula is effective for primary osteoporosis associated with depression in elderly.